Restless Legs Syndrome and Risk of Perinatal Depression

A recent study published in the Journal of Clinical Sleep Medicine investigated the relationship between restless legs syndrome (RLS) and the risk of perinatal depression. The research analyzed data from 2,435 pregnant Japanese women, followed from the second trimester until three months after delivery. The prevalence of RLS was 1.6% in the second trimester and 3.5% in the third trimester. During the follow-up period, 69 participants developed perinatal depression ¹.

Study Results

The results indicated that women with RLS had three times higher chances of developing perinatal depression and twice the chances of presenting depressive symptoms. The association was stronger when RLS occurred in the third trimester. These findings remained significant even after adjustments for factors such as age, education, marital status, occupation, number of children, and pregnancy planning ^1,2.

Restless legs syndrome is characterized by a strong and almost irresistible need to move the legs, often accompanied by uncomfortable sensations. These symptoms worsen during periods of rest and are temporarily relieved by movement, making it difficult to sleep. Previous studies had already shown that people with RLS have a higher prevalence of depression and anxiety ².

The authors suggest that screening for RLS during pregnancy may be important for the prevention of perinatal depression. Early identification of the syndrome can allow for timely interventions and better support for pregnant women ^1,2.